Trajenta Duo

Trajenta Duo

linagliptin + metformin

Manufacturer:

Boehringer Ingelheim
Concise Prescribing Info
Contents
Per 2.5/500 mg FC tab Linagliptin 2.5 mg, metformin HCl 500 mg. Per 2.5/850 mg FC tab Linagliptin 2.5 mg, metformin HCl 850 mg. Per 2.5/1,000 mg FC tab Linagliptin 2.5 mg, metformin HCl 1,000 mg
Indications/Uses
Adjunct to diet & exercise to improve glycaemic control in adults w/ type 2 DM when treatment w/ both linagliptin & metformin is appropriate, in patients already being treated & well controlled w/ the free combination of linagliptin & metformin. In combination w/ an SGLT2 inhibitor (ie, triple combination therapy) as an adjunct to diet & exercise in patients inadequately controlled on their max tolerated dose of metformin (≥1,500 mg/day) & an empagliflozin.
Dosage/Direction for Use
Individualized dosage. Recommended dose: 1 tab 2 times daily. Max daily dose: Linagliptin 5 mg, metformin 2,000 mg.
Administration
Should be taken with food.
Contraindications
Hypersensitivity. Diabetic ketoacidosis & pre-coma. Renal failure or dysfunction (CrCl <60 mL/min). Dehydration, severe infection, shock, concomitant administration of iodinated contrast agents. Cardiac or resp failure, recent MI. Acute alcohol intoxication; alcoholism. Hepatic insufficiency.
Special Precautions
Do not use in patients w/ type 1 diabetes or for the treatment of diabetic ketoacidosis. Hypoglycemia. Lactic acidosis. Monitor renal function before initiation of therapy & regularly thereafter. Renal impairment during initiating antihypertensive or diuretic & NSAID therapy. Discontinue use 48 hr before elective surgery w/ general, spinal or peridural anaesth, & if pancreatitis is suspected. Change in clinical status of patients w/ previously controlled type 2 diabetes. Pregnancy & lactation. Childn <18 yr. Elderly.
Adverse Reactions
Nasopharyngitis, hypersensitivity, cough, decreased appetite, diarrhoea, nausea, vomiting, pruritus. Pancreatitis. Increased lipase.
Drug Interactions
Metformin: Increased risk of lactic acidosis w/ alcohol. Increased plasma conc w/ concomitant use of cimetidine.
MIMS Class
Antidiabetic Agents
ATC Classification
A10BD11 - metformin and linagliptin ; Belongs to the class of combinations of oral blood glucose lowering drugs. Used in the treatment of diabetes.
Presentation/Packing
Form
Trajenta Duo 2.5/1,000 mg FC tab
Packing/Price
1 × 60's
Form
Trajenta Duo 2.5/500 mg FC tab
Packing/Price
1 × 60's
Form
Trajenta Duo 2.5/850 mg FC tab
Packing/Price
1 × 60's
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